Systemic NAD+ Boosting Therapies

Interventions that restore youthful levels of NAD+, a crucial metabolic cofactor that declines with age.

BACK TO EPOCH VIEW INTERACTIVE VERSION

Systemic NAD+ Boosting Therapies

Nicotinamide adenine dinucleotide (NAD+) is essential for mitochondrial function, DNA repair, and sirtuin activation. These therapies use precursors like NMN or NR, CD38 inhibitors, or direct NAD+ delivery to reverse age-related NAD+ decline, improving energy metabolism, genomic stability, and cellular stress resistance across multiple tissues.

TRL

6/9Demonstrated

Impact

4/5

Investment

3/5

Category

Applications

Connections

Caloric Restriction Mimetics

Compounds that reproduce the longevity benefits of caloric restriction without dietary limitation.

Hardware

Mitochondrial Augmentation Microdevices

Implantable systems that deliver healthy mitochondria directly into aging tissues.

Pharmacological Autophagy Induction

Drugs and compounds that activate cellular recycling pathways to clear damaged proteins and organelles.

Applications

Closed-Loop Metabolic Therapies

Automated systems that combine sensors, algorithms, and drug delivery to maintain youthful metabolic profiles.

Longevity Gene Augmentation

Gene therapy delivering variants of FOXO3, SIRT6, Klotho, and other longevity-associated genes.

Envisioning is an emerging technology research institute and advisory.

2011 — 2026