Pharmacological Autophagy Induction

Drugs and compounds that activate cellular recycling pathways to clear damaged proteins and organelles.

BACK TO EPOCH VIEW INTERACTIVE VERSION

Autophagy declines with age, leading to accumulation of cellular debris. Interventions like rapamycin (mTOR inhibition), spermidine, and novel autophagy enhancers restore this quality control system, removing dysfunctional mitochondria, misfolded proteins, and lipofuscin aggregates to improve cellular function and extend healthspan.

TRL

7/9Operational

Impact

4/5

Investment

3/5

Category

Applications

Connections

Applications

Small-Molecule Senolytics

Drugs that selectively eliminate senescent cells accumulating in aging tissues.

Caloric Restriction Mimetics

Compounds that reproduce the longevity benefits of caloric restriction without dietary limitation.

Applications

Systemic NAD+ Boosting Therapies

Interventions that restore youthful levels of NAD+, a crucial metabolic cofactor that declines with age.

Envisioning is an emerging technology research institute and advisory.

2011 — 2026