Closed-Loop Metabolic Modulators

Devices that actively modulate glucose, ketones, insulin signaling, or AMPK/mTOR pathways in real time.
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Implantable or wearable hardware that not only senses metabolic states but actively intervenes via micro-dosing pumps or neural stimulation. These systems maintain optimal metabolic parameters (e.g., glucose stability, ketone levels) automatically, keeping the body in a pro-longevity state without constant conscious management.

TRL
4/9Formative
Impact
4/5
Investment
4/5
Category
Hardware

Connections

Applications
Applications
Closed-Loop Metabolic Therapies

Automated systems that combine sensors, algorithms, and drug delivery to maintain youthful metabolic profiles.

TRL
6/9
Impact
4/5
Investment
4/5
Software
Software
Adaptive Metabolic Orchestration Engines

AI systems that continuously adjust diet, activity, sleep, and therapeutics to keep metabolism in a youthful state.

TRL
5/9
Impact
4/5
Investment
4/5
Hardware
Hardware
Implantable Multi-Omics Sensor Grids

Networks of implanted biosensors that continuously track molecular aging markers across the body.

TRL
4/9
Impact
5/5
Investment
4/5
Hardware
Hardware
Mitochondrial Augmentation Microdevices

Implantable systems that deliver healthy mitochondria directly into aging tissues.

TRL
3/9
Impact
5/5
Investment
4/5
Hardware
Hardware
Epigenetic Wearables

Noninvasive devices that track methylation drift, inflammation signatures, and mitochondrial output in real time.

TRL
3/9
Impact
4/5
Investment
4/5
Applications
Caloric Restriction Mimetics

Compounds that reproduce the longevity benefits of caloric restriction without dietary limitation.

TRL
7/9
Impact
4/5
Investment
3/5

Envisioning is an emerging technology research institute and advisory.

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2011 — 2026

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