Closed-Loop Metabolic Therapies

Automated systems that combine sensors, algorithms, and drug delivery to maintain youthful metabolic profiles.

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Closed-Loop Metabolic Therapies

Integrated therapeutic platforms linking continuous glucose, lipid, and hormone monitoring with infusion pumps and smart dosing algorithms. Building on artificial pancreas concepts, these systems orchestrate combinations of insulin, GLP-1 agonists, and other metabolic modulators in real time to prevent metabolic syndrome, preserve mitochondrial function, and support long-term healthspan.

TRL

6/9Demonstrated

Impact

4/5

Investment

4/5

Category

Applications

Connections

Closed-Loop Metabolic Modulators

Devices that actively modulate glucose, ketones, insulin signaling, or AMPK/mTOR pathways in real time.

Software

Adaptive Metabolic Orchestration Engines

AI systems that continuously adjust diet, activity, sleep, and therapeutics to keep metabolism in a youthful state.

Hardware

Implantable Multi-Omics Sensor Grids

Networks of implanted biosensors that continuously track molecular aging markers across the body.

Hardware

Mitochondrial Augmentation Microdevices

Implantable systems that deliver healthy mitochondria directly into aging tissues.

Applications

Systemic NAD+ Boosting Therapies

Interventions that restore youthful levels of NAD+, a crucial metabolic cofactor that declines with age.

Precision Microbiome Engineering

Targeted modification of gut microbiota to restore youthful metabolic and immune profiles.

Envisioning is an emerging technology research institute and advisory.

2011 — 2026