Caloric Restriction Mimetics

Compounds that reproduce the longevity benefits of caloric restriction without dietary limitation.
BACK TO EPOCHVIEW INTERACTIVE VERSION

Caloric restriction is the most robust lifespan-extending intervention across species, but difficult for humans. Mimetics like metformin, resveratrol, and NAD+ precursors activate similar pathways (AMPK, sirtuins, autophagy) without requiring reduced calorie intake, offering accessible pharmacological routes to healthspan extension.

TRL
7/9Operational
Impact
4/5
Investment
3/5
Category
Applications

Connections

Applications
Applications
Systemic NAD+ Boosting Therapies

Interventions that restore youthful levels of NAD+, a crucial metabolic cofactor that declines with age.

TRL
6/9
Impact
4/5
Investment
3/5
Applications
Pharmacological Autophagy Induction

Drugs and compounds that activate cellular recycling pathways to clear damaged proteins and organelles.

TRL
7/9
Impact
4/5
Investment
3/5
Software
Cross-Species Longevity Translation Models

AI systems that translate longevity interventions from model organisms to human therapeutics.

TRL
5/9
Impact
4/5
Investment
4/5
Hardware
Closed-Loop Metabolic Modulators

Devices that actively modulate glucose, ketones, insulin signaling, or AMPK/mTOR pathways in real time.

TRL
4/9
Impact
4/5
Investment
4/5
Applications
Applications
Small-Molecule Senolytics

Drugs that selectively eliminate senescent cells accumulating in aging tissues.

TRL
6/9
Impact
5/5
Investment
4/5
Applications
Longevity Gene Augmentation

Gene therapy delivering variants of FOXO3, SIRT6, Klotho, and other longevity-associated genes.

TRL
3/9
Impact
5/5
Investment
5/5

Envisioning is an emerging technology research institute and advisory.

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2011 — 2026

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