Small-Molecule Senolytics

Senescent cells secrete inflammatory factors (SASP) that drive tissue dysfunction. Senolytic compounds like dasatinib + quercetin, fisetin, and BCL-2 inhibitors selectively induce apoptosis in these cells. Clinical trials show improvements in physical function, reduction in age-related pathology, and potential lifespan extension in animal models with translation to human therapeutics underway.