Extracellular Matrix Remodeling Devices

Targeted ultrasound and enzymatic systems that break down aged, crosslinked ECM and stimulate fresh matrix deposition.
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Extracellular Matrix Remodeling Devices

Age-related tissue stiffening is driven by accumulated crosslinks (like advanced glycation end-products) in the extracellular matrix. These devices use focused ultrasound, light, or localized enzyme delivery to disrupt pathological crosslinks in skin, blood vessels, and organs, restoring tissue elasticity and improving cell-matrix signaling crucial for regeneration.

TRL
3/9Conceptual
Impact
4/5
Investment
3/5
Category
Hardware

Connections

Hardware
Hardware
Bioelectric Morphogenetic Arrays

Devices that map and modulate cellular bioelectric fields to guide limb and organ regeneration.

TRL
2/9
Impact
5/5
Investment
3/5
Hardware
Hardware
Mitochondrial Augmentation Microdevices

Implantable systems that deliver healthy mitochondria directly into aging tissues.

TRL
3/9
Impact
5/5
Investment
4/5
Hardware
Hardware
Whole-Organ Regeneration Bioreactors

Perfusion bioreactors that repair, rejuvenate, and recellularize donor or patient organs ex vivo.

TRL
5/9
Impact
5/5
Investment
5/5

Envisioning is an emerging technology research institute and advisory.

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2011 — 2026

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