Telomerase Gene Therapy

Controlled activation of telomerase to extend cellular replicative capacity without triggering cancer.
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Telomerase Gene Therapy

Telomeres shorten with each cell division, eventually triggering senescence. This therapy uses adeno-associated viral vectors or CRISPR activation to transiently express telomerase (TERT) in somatic tissues, extending cellular lifespan. Safety mechanisms include tumor suppressor monitoring, dose titration, and restriction to post-mitotic or slowly dividing cells.

TRL
3/9Conceptual
Impact
5/5
Investment
5/5
Category
Applications

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Applications
Longevity Gene Augmentation

Gene therapy delivering variants of FOXO3, SIRT6, Klotho, and other longevity-associated genes.

TRL
3/9
Impact
5/5
Investment
5/5
Applications
Applications
Partial Cellular Reprogramming

Controlled expression of Yamanaka factors to rejuvenate tissues without losing cellular identity.

TRL
4/9
Impact
5/5
Investment
5/5
Applications
Applications
Senolytic CAR-T Therapy

Engineering immune cells to target and destroy senescent 'zombie' cells that accumulate with age.

TRL
5/9
Impact
4/5
Investment
4/5

Envisioning is an emerging technology research institute and advisory.

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2011 — 2026

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