Longevity Gene Augmentation

Gene therapy delivering variants of FOXO3, SIRT6, Klotho, and other longevity-associated genes.
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Centenarian studies and model organisms have identified genetic variants correlated with extreme longevity. This therapy uses viral vectors or CRISPR base editing to introduce protective alleles or overexpress longevity genes in somatic tissues, enhancing stress resistance, DNA repair, and metabolic efficiency to extend healthy lifespan.

TRL
3/9Conceptual
Impact
5/5
Investment
5/5
Category
Applications

Connections

Applications
Applications
Telomerase Gene Therapy

Controlled activation of telomerase to extend cellular replicative capacity without triggering cancer.

TRL
3/9
Impact
5/5
Investment
5/5
Applications
Applications
Reproductive Longevity Therapeutics

Interventions specifically targeting ovarian aging to prolong fertility and delay systemic female aging.

TRL
4/9
Impact
5/5
Investment
5/5
Software
Cross-Species Longevity Translation Models

AI systems that translate longevity interventions from model organisms to human therapeutics.

TRL
5/9
Impact
4/5
Investment
4/5
Applications
Caloric Restriction Mimetics

Compounds that reproduce the longevity benefits of caloric restriction without dietary limitation.

TRL
7/9
Impact
4/5
Investment
3/5
Hardware
Hardware
Mitochondrial Augmentation Microdevices

Implantable systems that deliver healthy mitochondria directly into aging tissues.

TRL
3/9
Impact
5/5
Investment
4/5
Applications
Applications
Systemic NAD+ Boosting Therapies

Interventions that restore youthful levels of NAD+, a crucial metabolic cofactor that declines with age.

TRL
6/9
Impact
4/5
Investment
3/5

Envisioning is an emerging technology research institute and advisory.

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2011 — 2026

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