Engineered Thymic Organoid Grafts

Lab-grown thymus tissue implants designed to regenerate immune function lost with age.

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The thymus atrophies with age, leading to immune senescence and declining T-cell diversity. These grafts are grown from pluripotent stem cells and thymic epithelial progenitors, then surgically implanted or encapsulated in biocompatible scaffolds. They restore naive T-cell production, improving vaccine responses, cancer immunosurveillance, and infection resistance in the elderly.

TRL

4/9Formative

Impact

5/5

Investment

4/5

Category

Hardware

Connections

AI-Driven Immune Repertoire Maps

Models anticipating immune aging, thymus shrinkage dynamics, and T-cell diversity loss.

Applications

On-Demand Organoid Transplantation

Patient-specific mini-organs grown from stem cells to rejuvenate or replace failing tissues.

Hardware

Whole-Organ Regeneration Bioreactors

Perfusion bioreactors that repair, rejuvenate, and recellularize donor or patient organs ex vivo.

Applications

Senolytic CAR-T Therapy

Engineering immune cells to target and destroy senescent 'zombie' cells that accumulate with age.

Envisioning is an emerging technology research institute and advisory.

2011 — 2026