Skip to main content

Envisioning is an emerging technology research institute and advisory.

LinkedInInstagramGitHub

2011 — 2026

research
  • Reports
  • Newsletter
  • Methodology
  • Origins
  • Vocab
services
  • Research Sessions
  • Signals Workspace
  • Bespoke Projects
  • Use Cases
  • Signal Scanfree
  • Readinessfree
impact
  • ANBIMAFuture of Brazilian Capital Markets
  • IEEECharting the Energy Transition
  • Horizon 2045Future of Human and Planetary Security
  • WKOTechnology Scanning for Austria
audiences
  • Innovation
  • Strategy
  • Consultants
  • Foresight
  • Associations
  • Governments
resources
  • Pricing
  • Partners
  • How We Work
  • Data Visualization
  • Multi-Model Method
  • FAQ
  • Security & Privacy
about
  • Manifesto
  • Community
  • Events
  • Support
  • Contact
  • Login
ResearchServicesPricingPartnersAbout
ResearchServicesPricingPartnersAbout
  1. Home
  2. Research
  3. Cortex
  4. Optical & Ultrasonic Interfaces

Optical & Ultrasonic Interfaces

Light and sound waves that modulate neural activity without implants or surgery
Back to CortexView interactive version

Optical and ultrasonic interfaces are non-invasive or minimally invasive neural interfaces that utilize optogenetics (using light to control genetically modified neurons) or focused ultrasound (using acoustic waves for neuromodulation) to read and write neural activity deep within the brain without requiring physical contact with neural tissue, offering a safer path to bidirectional brain-computer interfaces that can both record from and stimulate the brain. These approaches avoid the risks associated with implanted electrodes while still providing access to deep brain structures, potentially enabling BCIs with much lower risk than traditional invasive approaches.

This innovation addresses the fundamental challenge of neural interfaces, where accessing deep brain structures typically requires invasive surgery. By using light or sound waves that can penetrate tissue, these approaches can interact with neurons without physical implants. However, optogenetics requires genetic modification of neurons, and ultrasound neuromodulation is still being refined. Research institutions and companies are developing these technologies.

The technology is particularly significant for enabling safer neural interfaces, where non-invasive or minimally invasive approaches could dramatically expand access to BCI technology. As the technology improves, it could enable new applications that aren't feasible with invasive approaches. However, ensuring effective neural control, managing specificity, and (for optogenetics) addressing the need for genetic modification remain challenges. The technology represents an important direction for safer neural interfaces, but requires continued development to achieve the performance and practicality needed for widespread use. Success could enable BCIs with much lower risk, but significant technical challenges must be overcome.

TRL
4/9Formative
Impact
5/5
Investment
4/5
Category
Hardware

Related Organizations

Synthetic Neurobiology Group (MIT)

United States · University

100%

Ed Boyden's lab at MIT.

Researcher
Kernel logo
Kernel

United States · Company

95%

Neuroscience company developing non-invasive brain recording technology (Flow and Flux).

Developer
GenSight Biologics

France · Company

90%

A clinical-stage biopharma company focusing on developing therapies for mitochondrial and neurodegenerative diseases of the eye.

Developer
Inscopix

United States · Company

85%

Developed miniature microscopes (miniscopes) for brain imaging.

Developer
Nanoscope Therapeutics

United States · Startup

85%

A clinical-stage biotechnology company developing gene therapies for retinal degenerative diseases.

Developer
NeuroLux logo
NeuroLux

United States · Startup

85%

A company providing battery-free, wireless optogenetics systems for neuroscience research.

Developer
Doric Lenses

Canada · Company

80%

A global leader in photonics solutions for life sciences, specifically neurophotonics.

Developer
Plexon

United States · Company

80%

A pioneer and leading innovator of custom, high-performance data acquisition, behavior and analysis solutions for scientific research.

Developer

Supporting Evidence

Evidence data is not available for this technology yet.

Connections

Hardware
Hardware
Next-Gen Noninvasive BCIs

Wearable brain sensors using magnetic fields and light to decode neural activity outside labs

TRL
6/9
Impact
4/5
Investment
4/5
Hardware
Hardware
Ultrasound Neuromodulation Devices

Non-invasive brain stimulation using focused ultrasound to modulate deep neural circuits

TRL
6/9
Impact
5/5
Investment
4/5
Hardware
Hardware
Endovascular Neural Interfaces

Stent-based electrodes implanted through blood vessels to record brain activity without open-skull surgery

TRL
7/9
Impact
5/5
Investment
5/5
Hardware
Hardware
Flexible Surface Arrays

Ultrathin electrode arrays that conform to the brain's surface for high-resolution neural recording

TRL
6/9
Impact
4/5
Investment
4/5
Hardware
Hardware
Implantable Neural Dust

Wireless grain-sized sensors injected into neural tissue to record brain activity

TRL
3/9
Impact
5/5
Investment
3/5
Hardware
Hardware
Bidirectional Peripheral Interfaces

Neural cuffs that read motor commands and deliver sensory feedback through peripheral nerves

TRL
5/9
Impact
5/5
Investment
4/5

Book a research session

Bring this signal into a focused decision sprint with analyst-led framing and synthesis.
Research Sessions